Evomec plus 1% similar TOLOMEC , ivermectin , clorsulon

Composition: 1 ml contains:
ivermectin……………………………….10 mg
clorsulon………………………………….100 mg
excipients: glycerol formal, propylene glycol.

Pharmacotherapeutic action: ivermectin is an antiparasitic substance from the class of macrocyclic lactones, isolated from the product obtained by fermentation of an actinomycete called Streptomyces avermitilis. It acts by increasing the permeability of the cell membrane to chloride ions with hyperpolarization of nerve or muscle cells, causing paralysis and death of the parasite; it also causes the secretion of gamma aminobutyric acid (GABA) at the level of the nerve synapses of the parasite, thus leading to the interruption of the nerve impulse. Clorsulon (benzenesulfonamide) acts on Fasciola spp. (immature and mature forms) by inhibiting enzymes in the glycolytic cycle (3-phosphoglycerol kinase and phosphoglycerol mutase). It is rapidly absorbed into the bloodstream, with effective plasma concentrations being reached approximately 8 hours after administration.

Target species: cattle.

Indications: in the treatment and control of infestations with:
– gastrointestinal nematodes (adults, L3, L4, inhibitory stages): Ostertagia spp; Bunostomum spp; Haemonchus spp; Toxocara spp; Trichostrongylus spp; Trichocephalus spp; Cooperia spp; Oesophagostomum spp; Nematodirus spp; Chabertia spp; Strongyloides spp.
– pulmonary nematodes: Dictyocaulus spp.
– trematodes (adults and immatures): Fasciola hepatica; Fasciola gigantica.
– scabies: Sarcoptes scabie var bovis; Choroptes bovis; Psoroptes bovis.
– entomoses: Hypoderma bovis (larval stages); Hypoderma lineatum (larval stages).
– ectoparasites: Linognatus vituli; Haematopinus eurystemus; Damalinia bovis; ticks.

Method of administration: it is administered strictly subcutaneously to cattle at a dose of 1 ml of product/50 kg of body weight. Usually the treatment is applied 2 times a year, spring and autumn, in a single dose, and in the case of scabies the treatment is repeated every 10-14 days.

Contraindications: it is not administered intramuscularly or intravenously. It is not administered in case of hypersensitivity to the active substances or to any of the excipients. It is not authorized for use in lactating animals that produce milk for human consumption. Transient edema may occur at the inoculation site. It can be used during gestation and lactation.