Floron injection x 100 ml, solution for injection contains 30 g fluorophenol

FLORON 100ml – solution for injection.

COMPOSITION
-100 ml solution for injection contains 30 g fluorofenicol.

SPECIES
Ruminants, pigs.

INDICATIONS
Cattle:
-Respiratory tract infections caused by Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus.
-Interdigital necrobacillosis (Fusobacterium necrophorum and Bacteroides melaninogenicus).
-Infectious keratoconjunctivitis (Moraxella bovis).
Swine:
– pleuropneumonia (Actinobacillus pleuropneumoniae);
– atrophic rhinitis (Pasteurella multocida, Bordetella bronchiseptica);
-Glasser’s disease (Haemophilus parasuis);
-Other diseases caused by microorganisms susceptible to fluorophenol (Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Salmonella cholerasuis and Streptococcus suis);

DOSAGE AND METHOD OF ADMINISTRATION
Cattle:
-i.m.: in the cervical region, maximum 10 ml in one place 20 mg/kg body weight (1 ml/15 kg);
-s.c.: in the cervical region, maximum 10 ml in one place 40 mg/kg body weight (2 ml/15 kg);

Swine:
– IM: in the cervical region, maximum 10 ml in one place 15 mg/kg body weight (1 ml/20 kg);

CONTRAINDICATIONS
Fluorophenol therapy is contraindicated during pregnancy or lactation, including in adult breeding boars. It should not be administered concomitantly with thiamphenicol or chloramphenicol-based products, nor should it be mixed with other medicines. The drug should not be administered to fish in tanks with a water temperature below 5ºC. In case of a higher water consumption, as a result of the high temperature in the animal sheds, the concentration of the drug in the water will be reduced by 25% or will be adjusted accordingly to the daily intake and the dose/kg of body weight.

PRESENTATION
Vials containing 100 ml solution for injection.

STORAGE CONDITIONS
At a maximum temperature of 25ºC, protected from light

ACTION
Fluorophenicol is a broad-spectrum synthetic antibiotic. It works by inhibiting protein synthesis in the bacterial cell. In protoplasm, the fluorophenol molecule binds to the 70 S ribosomal subunit, acts by inhibiting the peptide enzyme – transfers, causing the blocking of protein synthesis at the level of the ribosomes of susceptible bacteria. Fluorophenol is a derivative of thiamphenicol. Its molecule contains a fluorine atom instead of the hydroxyl group, thus being active against acetyl-transferase-producing bacteria and chloramphenico-resistant bacteria. Unlike chloramphenicol, the fluorophenol molecule does not contain the nitrogen group, which is responsible for producing aplastic anemia.

WAITING TIME
Meat and offal of cattle: 28 days.
Pork meat and offal: 14 days.