Clavaseptin 500mg, 10 tablets

Clavaseptin 500 mg 10 tablets – Chewable tablets against infections in dogs and cats

Indications:

Dogs:

For the treatment of gingivitis associated with periodontal infections caused by bacteria susceptible to amoxicillin / clavulanic acid.

For the treatment of skin and soft tissue, such as wounds and abscesses, caused by susceptible strains of Pasteurella spp., Staphylococcus spp. and Streptococcus spp.

Note: To limit the development of antimicrobial resistance this product should be used as directed. It is recommended to obtain culture samples and sensitivity testing before in vitro treatment.

For veterinary use ONLY.

Dosage form: Divisible tablets. Clavaseptin chewable tablets (500 mg)

Warning: Keep out of reach of children.

Adverse reactions: Vomiting and diarrhea may be observed.

Treatment may be continued depending on the severity of the observed adverse reaction, as determined by the attending veterinarian.
Hypersensitivity reactions (allergic skin reactions, anaphylaxis) are rarely observed.
In such cases, administration should be discontinued and symptomatic treatment given.
Pharmacology

Amoxicillin is an aminobenzylpenicillin of the β-lactam penicillin family that prevents bacterial cell wall formation by interfering with the final step of peptidoglycan synthesis.
Clavulanic acid is an inhibitor of intracellular and extracellular β-lactamases that protects amoxicillin from inactivation by several β-lactamases.
Amoxicillin/clavulanate has a broad spectrum of activity that includes β-lactamase-producing strains of both Gram-positive and Gram-negative aerobes, facultative anaerobes and obligate anaerobes.
The combination of amoxicillin and clavulanic acid has demonstrated in vitro activity against Pasteurella spp., Staphylococcus spp. and Streptococcus spp. isolated from cats with skin and soft tissue infections and against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria associated with gingivitis in dogs. Isolates of Pseudomonas spp. were generally found to be resistant in vitro to amoxicillin/clavulanic acid.

After oral administration at the recommended dose to dogs and cats, absorption of amoxicillin and clavulanic acid is rapid.

In dogs, peak plasma concentrations of amoxicillin of 8.5 pg/ml are reached in 1.4 h and peak plasma concentrations of clavulanic acid of 0.9 pg/ml are reached in 0.9 h.