Fasciozones , Oxyclozanide 50 mg/ml, internal antiparasitic for cattle, sheep, goats

COMPOSITION
1 ml of oral suspension contains:
Active substance:
Oxyclozanide …………………………………………………………………………….50 mg
Excipients:
Benzoic acid ……………………………………………………………………………….2 mg
Colloidal silicon dioxide, xanthan gum, polysorbate 80, ultrapurified
water.
INDICATIONS
It is recommended for the treatment of fasciolosis (Fasciola spp.),
paramphistomosis (Paramphistomum spp.) and cestodes (for
elimination of proglottis) in cattle, sheep and goats.
CONTRAINDICATIONS
Do not administer to animals with known hypersensitivity to the
active substance or any of the excipients.
ADVERSE REACTIONS
After the treatment, mild anorexia and diarrhea may occur. High
doses can cause blindness, hyperthermia, seizures and death, these
being the classic signs of inhibition of phosphorylation reactions at
the cellular level. Adverse reactions usually occur in highly stressed
animals, those with severe nutrition or metabolism problems or in
animals with strong parasitic infestations.
TARGET SPECIES
Cattle, sheep, goats.
ADMINISTRATION
Shake the bottle well before use. It is administered orally in doses
of: In cattle: 10 ml product/50 kg b.w. (10 mg oxyclozanide/kg b.w.).
Avoid exceeding the dose of 80 ml of product for one animal. In
sheep and goats: 3 ml product/10 kg b.w. (15 mg oxyclozanide/kg
b.w.). Avoid exceeding the dose of 15 ml of product for one animal.
To ensure a correct dose, the body weight must be determined as
accurately as possible to avoid overdose and of underdosing.
RECOMMENDATIONS FOR PROPER ADMINISTRATION
Shake the bottle before use.
SPECIAL WARNINGS FOR EACH TARGET SPECIES
To avoid the development of parasite resistance to the treatment with
anthelmintic, the following should be avoided:
• frequent and repeated use of anthelmintics from the same class for
a long period of time;
• underdosing by underestimating the body weight or following the
wrong administration of the veterinary medicinal product. A incorrect
dosage may favor the development of resistance to anthelmintics.
Clinical cases suspected of anthelmintic resistance should be
investigated using appropriate tests (eg Fecal Egg Count Reduction
Test). In the case of the development of parasite resistance to certain
anthelmintics use an anthelmintic from another pharmacological
class for treatment and with a different mode of action.
SPECIAL PRECAUTIONS FOR USE IN ANIMALS
After treatment the animals must be moved to a pasture without
intermediate hosts to avoid reinfestation.
USE DURING PREGNANCY, LACTATION
There are no restrictions on use.
OVERDOSE
The recommended doses will be observed. In the case of overdose
one notices the classic clinical signs of inhibition of phosphorylation
reactions (ATP synthesis), such as: blindness, hyperthermia,
convulsions and death. In case of overdose, consult your veterinarian.
WITHDRAWAL PERIOD
Cattle, sheep, goats: meat and offal – 14 days; milk – zero days
STORAGE
Store at a temperature below 25°C. Keep out of reach and sight of
children. Protect from direct light and frost. Keep in the original,
well-closed packaging. Do not use after the expiry date marked on
the bottle.

PRESENTATION
Bottles x 100 ml