Kanamycin FP 25% , Kanamycin sulfate 250 mg/ml

COMPOSITION
1 ml of solution for injection contains:
Active substance:
Kanamycin (as sulfate) ………………………………………………………….250 mg
Excipients:
Methyl parahydroxybenzoate …………………………………………………2.0 mg
Propyl parahydroxybenzoate ………………………………………………….0.2 mg
Sodium citrate, sodium bisulfite, water for injections.
INDICATIONS
In horses, cattle, pigs, sheep, goats, dogs, cats and hens in the
treatment of urogenital, respiratory, digestive infections, mastitis,
salmonellosis, mycoplasmosis, endometritis, sepsis , skin infections,
abscesses, phlegmons and secondary infections in viral diseases.
CONTRAINDICATIONS
Do not use in animals with renal failure. It is not used in case of
hypersensitivity to the active substance or to any of excipients.
ADVERSE REACTIONS
It sometimes causes pain at the injection site.
TARGET SPECIES
Horses, cattle, sheep, goats, pigs, hens, dogs, cats.
ADMINISTRATION
It is administered intramuscularly or subcutaneously (preferably
divided at 12-hour intervals) in the following doses:
Horses, cattle: 2 ml product / 100 kg b.w./ day.
Pigs, sheep, goats: 2 ml product / 50 kg b.w./ day.
Dogs, cats: 0.1 ml product / kg b.w./ day.
Hens: 0.1 ml product / kg b.w./ day.
The administration time is 3-5 days depending on the evolution of
the condition. If the animals do not show an improvement in their
health condition, the veterinarian will be consulted for re-evaluation
of the diagnosis.
RECOMMENDATIONS FOR PROPER ADMINISTRATION
In order to ensure a correct dosage, the body weight of the animals
must be determined as precisely as possible.
USE DURING PREGNANCY, LACTATION OR LAYING PERIOD
No specific information on the safety and efficacy of the product
during pregnancy is available. It is used only in accordance with the
benefit/risk assessment carried out by the responsible veterinarian.
It may produce teratogenic effects during pregnancy. It can be used
during lactation.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS OR OTHER
FORMS OF INTERACTION
The simultaneous administration of other antibiotics
(chloramphenicol, tetracycline) or other aminoglycosides should
be avoided. The simultaneous administration of cephalosporins
or diuretics increases ototoxicity and nephrotoxicity of kanamycin.
Kanamycin is inactivated by methicillin. Kanamycin decreases the
absorption of vitamin K, thus enhancing the action of anticoagulants
(for example, acetocoumarol). Cross-resistance occurs between
kanamycin, neomycin and paromomycin. Unidirectional resistance
to streptomycin is recognized.
OVERDOSE
Symptoms of overdose may include: ototoxicity, nephrotoxicity and
neuromuscular blockade.
INCOMPATIBILITIES
It forms precipitates with solutions for injections containing
aminophylline, amphotericin B, novobiocin, carbenicillin, phenobarbital
sodium, sodium heparin, sulfisoxazole, sulfamethoxypyridazine,
oxytetracycline, sodium pentobarbital, vitamin B complex.
Incompatibilities have also been reported solutions for injections
containing glucose, oxacillin, sodium bicarbonate, protein
hydrolysate, polymyxin B, calcium gluconate, procaine hydrochloride,
lidocaine hydrochloride.
WITHDRAWAL PERIOD
Meat and offal: horses, cattle, sheep, goats, pigs, hens – 10 days.
Milk: cattle, sheep, goats – 36 hours. Not permitted for use in laying
hens that produce eggs for human consumption.
STORAGE
Store at a temperature below 25°C.
Protect from light. Keep the bottle tightly closed. Protect from frost.

PRESENTATION
Bottles x 100 ml