Pessaries with foaming and effervescent action , with oxytetracycline and neomycin

COMPOSITION
1 pessary contains:
Active substances:
Oxytetracycline hydrochloride ………………………………………………250 mg
Neomycin sulfate ………………………………………………………………….250 mg
Excipients:
Citric acid, sodium bicarbonate, sodium lauryl sulfate, magnesium
stearate, talc, polyvinylpyrrolidone K30.
INDICATIONS
The product is recommended for horses, cattle, sheep, goats, pigs
and dogs in placental retention, uterine and vaginal prolapse,
dystocia accompanied by tissue damage, various types of surgery
on the uterus, cervicitis, vaginitis, metritis, acute and chronic
endometritis.
CONTRAINDICATIONS
Do not administer in case of hypersensitivity to the active substances
or to any of the excipients.
ADVERSE REACTIONS
They were not reported.
TARGET SPECIES
Horses, cattle, sheep, goats, pigs, dogs.
ADMINISTRATION
The product is administered manually or with the help ofa clamp,
into the vaginal or uterine cavity. The doses and duration of the
treatment are determined by species. Horses, cattle: 4 – 6 pessaries
daily, for 3 – 4 days. Sheep, goats, pigs: 2 – 3 pessaries daily, for 2 – 3
days. Dogs: 1/2 pessary daily, for 2 – 3 days.
USE DURING PREGNANCY, LACTATION
It is not used during pregnancy.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS OR OTHER
FORMS OF INTERACTION
The combination of the product with calcium, magnesium, manganese,
iron, aluminum salts, may lead to the formation of inactive
compounds of oxytetracycline. The simultaneous administration of
the product with methotrexate, due to the presence of neomycin,
decreases its absorption , increasing intestinal excretion while
also decreasing urinary excretion. In case of administration of the
product simultaneously with dimenhydrinate, the early symptoms of
neomycin-induced ototoxicity are masked. The combination of the
product with streptomycin, kanamycin, gentamicin, paromomycin
and colistin which add their toxicity to that of the neomycin sulfate
may lead to kidney damage.
Association of the product with anesthetics , due to the presence of
neomycin, may lead to neuromuscular blockade.
INCOMPATIBILITIES
The product is not administered together with streptomycin,
kanamycin, gentamicin and colistin, because they increase the
toxicity of neomycin for the kidneys. It should also not be associated
with anesthetics because they can cause neuromuscular blockade.
It is not associated with calcium, magnesium, manganese, iron,
aluminum salts that lead to the formation of inactive oxytetracycline
compounds.
WITHDRAWAL PERIOD
Meat: – cattle, sheep, goats, pigs – 4 days. Milk: – 3 days. It is not
allowed to use in horses whose meat is intended for human
consumption.
STORAGE
Store at a temperature below 25°C. Protect from frost. Keep in the
original packaging. Protect from direct light. Keep in a tightly closed
packaging. Store in a dry place.

PRESENTATION
Bottles x 25 pessaries