Neomycin sulfate FP 10% , 100 mg/g

COMPOSITION
1 g of powder contains:
Active substance:
Neomycin (as sulfate) ……………………………………………………………100 mg
Excipient:
Lactose monohydrate.
INDICATIONS
The product is recommended in the treatment of bacterial enteritis
produced by neomycin-susceptible bacteria in leisure horses, cattle
(calves), sheep (lambs), goats (kids), pigs (piglets), chickens (laying
hens and broilers), dogs, cats and minks.
CONTRAINDICATIONS
Do not administer in case of hypersensitivity to the active substance
or to the excipient.
ADVERSE REACTIONS
None reported.
TARGET SPECIES
Leisure horses, cattle (calves), sheep (lambs), goats , pigs
(piglets), chickens (laying hens and broilers), dogs, cats, minks.
ADMINISTRATION
The product is administered orally, individually or collectively,
in drinking water, in different doses depending on the condition,
species and animal category. Leisure horses, cattle (calves), sheep
(lambs), goats (kids), pigs (piglets), dogs, cats, minks: 70 – 210 mg
of NEOMYCIN SULFATE FP 10% powder (7 – 21 mg a.s.) /kg .b.w. /
day, for 14 days, depending on the evolution of the disease. Chickens
(laying hens and broilers): 70 – 210 mg of NEOMYCIN SULFATE FP
10% powder (7 – 21 mg a.s.) /kg .b.w./day, for 3 – 5 days. The weight
of animals/birds (in kg) is estimated and requirement for a day is
calculated , which is added to the amount of water intended to be
consumed within 12 – 24 hours: 2 g of NEOMYCIN SULFATE FP 10%
powder /10 kg .b.w. In order to ensure proper dosage, the body
weight of the animals should be accurately determined, whenever
possible, to avoid under-dosing.
RECOMMENDATIONS FOR PROPER ADMINISTRATION
The product should not be administered as such. For group
treatment, it is recommended to correctly calculate the total body
weight and doses to be administered, as well as ensuring a good
homogenizations. The medicated water must be consumed entirely
in the day of preparation.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS OR OTHER
FORMS OF INTERACTION
Neomycin administered orally together with penicillin V and vitamin
K causes poor absorption of penicillin and decreases the absorption
of vitamin K, thus potentiating the action of anticoagulants. Neomycin
also decreases the absorption of methotrexate, increasing intestinal
excretion, while decreasing urinary excretion due to reduced
metabolism. Administered concomitantly with dimenhydrinate,
it masks the early symptoms of neomycin-induced ototoxicity.
Association with streptomycin, kanamycin, gentamicin, paramomycin
and colistin, which add their toxicity to that of neomycin sulfate, may
lead to kidney damage. Association with anesthetic substances can
produces neuromuscular blockade.
OVERDOSE
Due to the poor absorption of neomycin, overdose should be avoided.
The recommended doses will be observed.
INCOMPATIBILITIES
Neomycin sulfate should not be administered together with
streptomycin, kanamycin, gentamicin and colistin because they
increase the toxicity of neomycin on the kidneys. It should also not
be associated with anesthetic substances because they can produce
neuromuscular blockade.
WITHDRAWAL PERIOD
Meat and offal: calves, lambs – 5 days, piglets – 4 days, laying
hens, broiler chicks – 3 days. Eggs: zero days. It is not authorized for
use in horses intended for consumption human.
STORAGE
Store at a temperature below 25°C. Protect from frost. Keep in the
original packaging. Protect from direct light. Keep in the tightly
closed packaging. Store in a dry place.

PRESENTATION
Bags x 100 g