Florcrid anti-infective injectable

NAME OF VETERINARY MEDICINAL PRODUCT
FLORCRID, solution for injection for cattle and pigs.

DECLARATION OF ACTIVE SUBSTANCE AND OTHER INGREDIENTS
1ml. product contains:
Florfenicol……………………… 300 mg.
Propylene glycol
N-methyl-pyrrolidone,
Macrogol 300.

INDICATIONS:
In the treatment of diseases caused by germs sensitive to florfenicol.
Cattle:
Preventive (in flocks where the diagnosis has been confirmed) and curative treatment of respiratory tract infections caused by Manheimia haemolytica, Pasteurella multocida and Histophilus somni.
Swine:
Treatment of acute respiratory infections caused by Actinobacillus pleuropneumoniae and Pasteurella multocida.

CONTRAINDICATIONS
It is not administered to adult bulls and boars used for breeding.
Do not administer in case of known sensitivity to the active substance or excipients. Do not use in piglets smaller than 2 kg. Do not administer to piglets smaller than 2 kg.

ADVERSE REACTIONS
Cattle:
There may be a reduction in the consumption of feed, soft fecal matter during the treatment. When the treatment is interrupted, the animals quickly and completely regain their appetite. Intramuscular or subcutaneous administration may be accompanied by inflammatory lesions at the injection site, which persist for 14 days. In very rare cases, cases of anaphylactic shock in cattle have been reported. Usually these reactions are mild and transient.
Swine:
The most common side effects are manifested by transient diarrhea, erythema, perianal and rectal edema in 50% of the animals over a period of one week. Under field conditions, one week or more after the last dose administered, approximately 30% of pigs exhibit hyperthermia (400 C) associated with dyspnea and depression. Edema may occur at the injection site over a period of 5 days. Inflammatory lesions at the injection site can be seen for 28 days.

TARGET SPECIES:
Cattle, pigs.

DOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION
Cattle:
Treatment:
Intramuscular administration: 20 mg. florfenicol/kg. body weight or 1 ml. of product/15 kg. body weight, 2 times every 48 hours.
Subcutaneous administration: 40 mg. florfenicol/kg. body weight or 2 ml. product/15 kg. body weight, a single administration.
Preventive:
Subcutaneous administration: 40 mg. florfenicol/kg. body weight or 2 ml. product/15 kg. body weight, a single administration.
Swine:

Intramuscular administration: 15 mg. florfenicol/kg. body weight or 1 ml. of product/ 20 kg. body weight, 2 times every 48 hours.
The weight of the animal is evaluated as correctly as possible to ensure a dose and avoid underdosing.

RECOMMENDATIONS ON CORRECT ADMINISTRATION
For intramuscular administration, it is recommended to treat animals in the early phase of the disease and evaluate the response to treatment 48 hours after the second administration. If the clinical signs of respiratory disease persist for 48 hours after the last injection, the treatment should be changed using another formula or antibiotic and continued until the clinical signs disappear. Wipe off the cap before taking each dose. Use sterile syringes and dry needles. Do not prick the lid more than 25 times. The injections should be performed in the neck with a needle number 16. The volume of the dose administered in one place should not exceed 10 ml in cattle and 3 ml. in pigs.

WAITING TIME
Cattle (meat and offal) 30 days (intramuscular administration) 44 days (subcutaneous administration).
Pigs (meat and offal) 18 days.
The product is not authorised for use in animals producing milk for human consumption.

USE DURING PREGNANCY OR LACTATION
Studies in laboratory animals have not shown an embryotoxic or foetotoxic potential of florfenicol. However, the safety of the product in target species has not been demonstrated on reproductive performance, gestation and lactation. The use of the product is made after the evaluation of the benefit/risk balance by the veterinarian.

OVERDOSE
Cattle:
There may be a reduction in the consumption of feed, soft fecal matter during the treatment. When the treatment is interrupted, the animals quickly and completely regain their appetite.
Swine:
After taking a dose 3 times higher than the recommended dose, a decrease in weight gain, food and water intake was observed. After taking a dose 5 times higher than the recommended dose, vomiting may occur.

PRESENTATION
Polypropylene bottles, 100ml and 250ml closed with brombutyl rubber stopper and aluminum staple.