Neoxivit oral powder, 100 g , treatment of digestive infections for calves, lambs, piglets

COMPOSITION
1 g of product contains:
Active substances:
Neomycin sulfate ……………………………………………………………………55 mg
Oxytetracycline hydrochloride …………………………………………………55 mg
Vitamin B1…………………………………………………………………………………6 mg
Vitamin B2 …………………………………………………………………………………6 mg
Vitamin B6 ………………………………………………………………………………14 mg
Vitamin B12 ………………………………………………………………………….0.03 mg
Excipient:
Lactose monohydrate
INDICATIONS
In the treatment of digestive infections caused by germs sensitive to
oxytetracycline and neomycin in suckling piglets and weaned piglets
in case of enteritis produced by E. coli and Salmonella spp. In the
treatment of bacterial enteritis, pneumonia and bronchopneumonia
in calves, lambs and young sheep, as well as in the treatment of
other infections caused by Gram-negative germs and Gram-positive
germs sensitive to oxytetracycline and neomycin.
CONTRAINDICATIONS
It is not administered in case of bowel obstruction and in animals
with renal failure. Do not use in case of hypersensitivity to the active
substances or any of the excipients.
ADVERSE REACTIONS
Rarely, neomycin administered orally may produce ototoxicity,
nephrotoxicity and severe diarrhea.
TARGET SPECIES
Calves, lambs, piglets.
ADMINISTRATION
The product is administered orally. Prepare a 20% aqueous
suspension to be administered individually. The treatment is
administered at an interval of 12 hours, for 3 – 5 days, in the following
doses (corresponding to a daily dose of 11 mg of oxytetracycline
hydrochloride/ kg b.w. and 11 mg of neomycin sulfate/kg b.w.):
Suckling piglets (0 – 10 days): 2.5 – 3 ml/ animal, every 12 hours.
Suckling piglets (10 – 25 days): 5 ml/10 kg b.w. at 12 hour intervals.
Piglets: 5 ml/ 10 kg b.w., every 12 hours. Lambs and young sheep
(0–4 months and 4–8 months respectively): 10 ml/ 20 kg b.w., at 12
hour intervals. Calves: 5 grams of product dissolved into 250 ml of
herbal infusion, at intervals of 12 hours.
RECOMMENDATIONS FOR PROPER ADMINISTRATION
The product should not be administered as such. The powder
should be properly dissolved into drinking water/herbal infusion
before use. In order to ensure proper dosing, the body weight of
the animals should be accurately determined, whenever possible, to
avoid underdosing.
INTERACTIONS WITH OTHER MEDICINAL PRODUCTS AND
OTHER FORMS OF INTERACTION
Oxytetracycline acts antagonistically with penicillin. It is inactivated
by sodium lactate, oxacillin, promethazine. Neomycin administered
orally together with penicillin V causes poor absorption of penicillin.
Although only small amounts of neomycin are absorbed after oral
administration, simultaneous use of other ototoxic or nephrotoxic
medicines should be done with caution. Neomycin sulfate is not
administered together with streptomycin, kanamycin, gentamicin,
colistin because they increase the toxicity of neomycin for the
kidneys. It should also not be associated with anesthetics because
they can produce neuromuscular blockade.
OVERDOSE
Tetracycline overdose causes intestinal dysmicrobism, nephrotoxicity,
or side effects on calcification. Due to poor absorption of neomycin,
overdose must be avoided. The recommended doses will be
observed.
WITHDRAWAL PERIOD
Meat and offal:
Lambs – 5 days.
Calves – 7 days.
Piglets – 5 days.
STORAGE
Store at a temperature below 25°C. Protect from direct light. Store
in a dry place.

PRESENTATION
Bags x 100 g