Eqvamec P 20 mg/ml, oral paste for horses

COMPOSITION
Each ml of paste contains:
Ivermectin………………………………………………. 20 mg
Excipients:
Methyl parahydroxybenzoate..……………………………… 1.8 mg
Propyl parahydroxybenzoate……………………………….. 0.2 mg

PHARMACOTHERAPEUTIC ACTION
EQVAMEC-P, through its active ingredient – ​​ivermectin, acts on both endoparasites (nematodes) and ectoparasites in horses. Ivermectin is a derivative of avermectin, isolated from the product obtained by fermentation of an actinomycete called Streptomyces avermitilis. In nematodes, ivermectin stimulates the production of GABA (gamma aminobutyric acid), at the level of the neuronal synapse and intensifies the GABA binding to special receptors, thus interrupting the transmission of nerve impulses at the level of nerve junctions, paralyzing and killing the parasite. In arthropods, the interruption of nerve impulses occurs at the level of the neuromuscular synapse. This leads to paralysis and death of the parasite.

TARGET SPECIES
Horses.

INDICATIONS
EQVAMEC-P paste, administered at the recommended dose, acts against the following:
A. Nematodes present in:
– stomach: Habronema spp.; Trichostrongylus axei
– small intestine: Parascaris equorum,Strongyloides westeri
– large intestine: Strongylus vulgaris, Strongylus edentatus, Strongylus equinus, Triodontophorus spp., Cyathostomum spp., Oxyurus equi
– lung: Dictyocaulus arnfieldi
– muscle and skin: Habronema spp., Onchocerca spp.
B. Arthropods: Gasterophilus spp.
C. Mites: Sarcoptes, Psoroptes, Chorioptes
In special cases, treatment with EQVAMEC-P does not exclude the application, in parallel, of an appropriate local therapy for serious wounds caused by skin parasites. All horses in the herd should be included in a regular and strict deworming program with increased attention to mares, young horses and foals. Foals should be treated initially at the age of 6 – 8 weeks. Regular treatments will reduce the chances of verminous arteritis and colic caused by Strongylus vulgaris.

DOSAGE, ROUTE AND METHOD OF ADMINISTRATION
It is administered orally.
The dose of EQVAMEC-P paste is: 1 ml paste / 100 kg g.c., respectively one graduation of the dosing syringe piston /100 kg g.c. (20 mg ivermectin/100 kg g.c.). The content of the syringe is sufficient to treat 600 kg g.c. Insert the syringe into the horse’s oral cavity, in the interdental space, as deep as possible, depositing the medicine at the base of the tongue. Immediately after administration, raise the animal’s head for a few seconds. Before administering the paste, care must be taken to ensure that there is no feed in the oral cavity.
If the animals do not show an improvement in their health, consult a veterinarian for a reassessment of the diagnosis.

CONTRAINDICATIONS, PRECAUTIONS AND ADVERSE REACTIONS
Do not administer to foals under 6 weeks of age. EQVAMEC-P is not administered to other animal species.
Do not administer in case of hypersensitivity to the active substance or to any of the excipients. Particular attention should be paid to pregnant animals and animals stressed due to malnutrition, adverse weather conditions, being in a pen, etc.
The recommended doses have a very wide margin of protection for animals. Following administration of the product to horses heavily infested with Onchocerca microfilariae, edema and pruritus may occur, due to the death of the large number of microfilariae. In case of prolonged administration, irreversible disorders of the sense of balance may occur. It can be used during pregnancy or lactation. In horses, oral administration of a dose of 1.8 mg/kg (i.e. 9 x the recommended dose) did not produce any symptoms of toxicity, but at 2 mg/kg, visual disturbances, depression and ataxia were observed.
No specific antidote is known. In case of poisoning, symptomatic treatment is instituted.

WITHDRAWAL TIME
Meat: 28 days.

STORAGE CONDITIONS
Store below 25°C. Protect from direct light. Protect from frost.